Enable MST on the Switch:

Switch # configure terminal

Switch (config) # spanning-tree mode mst

Define the MST Region:

Switch (config) # spanning-tree mst configuration

Switch (config-mst) # name

Switch (config-mst) # revision

region-name: Specify a name for the MST region.

revision-number: Assign a revision number to the MST region. This number helps switches determine whether they are running the same MST configuration. 

Note: MST region name and revision number should be same on both local and neighbor switch. 

Map VLANs to MST Instances:

Switch (config-mst) # instance vlan

instance-id: Specify the MST instance ID.

vlan-range: Define the VLANs to be mapped to the MST instance.

You can configure multiple instances, each with its own VLAN mapping.

Assign Switch Priority:

Switch (config) # spanning-tree mst priority

instance-id: Specify the MST instance ID.

priority-value: Assign a priority value to the switch. Lower values indicate higher priority.

we can use lower priority to make a switch as root for an MST instance or we can also use root primary and secondary command to do the same. 

or

Switch (config) # spanning-tree mst instance root primary

Switch (config) # spanning-tree mst instance root secondary

Verify the MST Configuration:

Switch # show spanning-tree mst configuration

Switch # show spanning-tree mst

Switch # show spanning-tree mst configuration